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R-7050

R-7050 (TNF-α Antagonist III) is a tumor necrosis factor receptor (TNFR) antagonist with greater selectivity toward TNFα.

Product Specifications

CAS Number

[303997-35-5]

Product Name Alternative

TNF-α Antagonist III

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/R-7050.html

Purity

99.96

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

FC(F)(C1=NN=C2N1C3=CC(Cl)=CC=C3N=C2SC4=CC=CC=C4)F

Molecular Formula

C16H8ClF3N4S

Molecular Weight

380.77

Precautions

H302, H315, H319, H335

References & Citations

[1]Gururaja TL, et al. A class of small molecules that inhibit TNFalpha-induced survival and death pathways viaprevention of interactions between TNFalphaRI, TRADD, and RIP1. Chem Biol. 2007 Oct;14 (10) :1105-18.|[2]King MD, et al. TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebralhemorrhage in mice. Neurosci Lett. 2013 May 10;542:92-6.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-110203/R-7050-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-110203/R-7050-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TNFRSF5/CD40

Available Sizes

Curated Selection

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