NCGC00029283
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].
Product Specifications
CAS Number
714240-31-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ncgc00029283.html
Purity
98.88
Solubility
DMSO : 6.94 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NC2=C(C=C(OC)C=C2)C=C1C3=NOC(C4=CC=C(F)C=C4)=N3
Molecular Formula
C18H12FN3O3
Molecular Weight
337.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN) . PLoS One. 2019 Jan 9;14 (1) :e0210525.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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