NCGC00029283

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively[1].

Product Specifications

CAS Number

[714240-31-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ncgc00029283.html

Purity

98.88

Solubility

DMSO : 6.94 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NC2=C(C=C(OC)C=C2)C=C1C3=NOC(C4=CC=C(F)C=C4)=N3

Molecular Formula

C18H12FN3O3

Molecular Weight

337.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Joshua A Sommers, et al. A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN) . PLoS One. 2019 Jan 9;14 (1) :e0210525.