Pinoresinol
Pinoresinol is a lignol of plant origin serving for defense in a caterpillar. Pinoresinol drastically sensitizes cancer cells against TNF-related apoptosis-inducing ligand (TRAIL) -induced apoptosis[1][2].
Product Specifications
CAS Number
487-36-5
Product Name Alternative
(+) -Pinoresinol
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pinoresinol.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=C(O)C=CC([C@@H]2[C@]3([H])[C@]([C@@H](C4=CC(OC)=C(O)C=C4)OC3)([H])CO2)=C1
Molecular Formula
C20H22O6
Molecular Weight
358.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Schroeder FC, et al. Pinoresinol: A lignol of plant origin serving for defense in a caterpillar. Proc Natl Acad Sci U S A. 2006 Oct 17;103 (42) :15497-501.|[2]Lee SR, et al. Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis. Sci Rep. 2019 Sep 18;9 (1) :13505.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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