Mps1-IN-2
Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor, with an IC50 and a Kd of 145 nM and 12 nM for Mps1 and a Kd of 61 nM for Plk1.
Product Specifications
CAS Number
[1228817-38-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mps1; Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Mps1-IN-2.html
Concentration
10mM
Purity
98.08
Solubility
DMSO : 13.33 mg/mL (ultrasonic)
Smiles
CN(C1=CN=C(NC2=C(OCC)C=C(N3CCC(O)CC3)C=C2)N=C1N(C4CCCC4)CC5)C5=O
Molecular Formula
C26H36N6O3
Molecular Weight
480.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Kwiatkowski N, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May;6 (5) :359-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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