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Naspm (trihydrochloride)

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

Product Specifications

CAS Number

[1049731-36-3]

Product Name Alternative

1-Naphthylacetyl spermine trihydrochloride

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Naspm-trihydrochloride.html

Purity

98.50

Solubility

DMSO : 6.4 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

[H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1

Molecular Formula

C22H37Cl3N4O

Molecular Weight

479.91

References & Citations

[1]Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29 (1) :27-36.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AMPA Receptor

Citation 01

Cell Rep. 2020 Nov 10;33 (6) :108369.|Cell Rep. 2023 Dec 3;42 (12) :113551.|iScience. 2023 Mar 3;26 (4) :106322.|J Headache Pain. 2022 Aug 10;23 (1) :98.|Neurobiol Dis. 2024 May:194:106471.|Neuroscience. 2021 Nov 1:475:220-228.|Toxicol In Vitro. 2017 Oct:44:57-65.

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