Naspm (trihydrochloride)

Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.

Product Specifications

CAS Number

[1049731-36-3]

Product Name Alternative

1-Naphthylacetyl spermine trihydrochloride

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Naspm-trihydrochloride.html

Purity

98.50

Solubility

DMSO : 6.4 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

[H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1

Molecular Formula

C22H37Cl3N4O

Molecular Weight

479.91

References & Citations

[1]Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29 (1) :27-36.