Naspm (trihydrochloride)
Product Specifications
Product Name Alternative
1-Naphthylacetyl spermine trihydrochloride
UNSPSC Description
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist.
Target Antigen
iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Naspm-trihydrochloride.html
Purity
98.50
Solubility
DMSO : 6.4 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.[H]Cl.[H]Cl.O=C(NCCCNCCCCNCCCN)CC1=C2C=CC=CC2=CC=C1
Molecular Weight
479.91
References & Citations
[1]Koike M, et al. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neurosci Res. 1997 Sep;29(1):27-36.Cell Rep. 2020 Nov 10;33(6):108369. |Cell Rep. 2023 Dec 3;42(12):113551.|iScience. 2023 Mar.|J Headache Pain. 2022 Aug 10;23(1):98.|Neurobiol Dis. 2024 Mar 8:106471.|Neuroscience. 2021 Sep 9;S0306-4522(21)00454-1.|Toxicol In Vitro. 2017 Oct;44:57-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12506A/Naspm-trihydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12506A/Naspm-trihydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1049731-36-3
Available Sizes
Curated Selection
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