GNE-149

GNE-149 is an orally bioavailable full antagonist of estrogen receptor α (ERα; IC50=0.053 nM) . GNE-149 is a selective estrogen receptor degrader (SERD) . GNE-149 can be used for the research of breast cancer[1].

Product Specifications

CAS Number

[1953132-75-6]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gne-149.html

Concentration

10mM

Purity

99.18

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C)(F)CN1[C@@](C2=C(C=C(C=C2F)OC3CN(C3)CCCF)F)([H])C4=C(C[C@H]1C)C5=CC=CC=C5N4

Molecular Formula

C28H33F4N3O

Molecular Weight

503.57

References & Citations

[1]Jun Liang, et al. Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer. ACS Med Chem Lett. 2020 May 26;11 (6) :1342-1347.