Human PDE4A Protein, His Tag (MALS verified)
Human PDE4A Protein, His Tag (PDA-H55H3) is expressed from Baculovirus-Insect cells. It contains AA Pro 331 - Met 723 (Accession # P27815-1) .
Product Specifications
Background
CAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A) is an enzyme that in humans is encoded by the PDE4A gene. It belongs to the PDE family who hydrolyze 3′-5′-cyclic adenosine monophosphate (cyclic AMP) to 5′-adenosine monophosphate (AMP) . PDE enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as in various neurologic, dermatological, and inflammatory diseases.
Specifications
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 47.1 kDa. The protein migrates as 45-52 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Accession Number
P27815-1
Expression Region
Pro 331 - Met 723
Host
Insect Cells
Target
PDE4A
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Liquid
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Glycerol
Molecular Weight
47.1 kDa
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
50ug*1
Product Datasheet
Https://www.acrobiosystems.com/static/main/products/pdf/ds/PDA-H55H3.pdf
Species
Human
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
