Human PDE4A Protein, His Tag (MALS verified)
CAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A) is an enzyme that in humans is encoded by the PDE4A gene. It belongs to the PDE family who hydrolyze 3′-5′-cyclic adenosine monophosphate (cyclic AMP) to 5′-adenosine monophosphate (AMP) . PDE enzyme family plays a pivotal role in regulating levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been investigated as a therapeutic strategy to enhance cAMP signaling in a broad range of diseases, including several types of cancers, as well as in various neurologic, dermatological, and inflammatory diseases.
Product Specifications
Background
Specifications
Accession Number
P27815-1
Expression Region
Pro 331 - Met 723
Host
Insect Cells
Target
PDE4A
Conjugation
Unconjugated
Tag
C-10xHis
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Purity
90%
Format
Liquid
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Glycerol
Molecular Weight
47.1 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
50ug*1
Host or Source
InsectCells
Species
Human
Protein ID
P27815-1
Preservative
Glycerol
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