Antitumor agent-159

Antitumor agent-159 (Compound 13b) targets the mitochondria and downregulates cardiolipin levels. Antitumor agent-159 inhibits the proliferation of cancer cell MDA-MB-231, arrests the cell cycle at sub-G1 phase, and induces apoptosis in MDA-MB-231. Antitumor agent-159 exhibits antitumor efficacy in MDA-MB-231 xenograft mouse models[1].

Product Specifications

CAS Number

[1611446-66-2]

Product Name Alternative

Pentacarboxybenzene

UNSPSC

12352005

Target

Apoptosis; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antitumor-agent-159.html

Purity

99.0

Smiles

ClC1=CC=C(C=C1C(F)(F)F)NC(NCCCCCCCCCCCCCCCC(O)=O)=O

Molecular Formula

C24H36ClF3N2O3

Molecular Weight

493.00

References & Citations

[1]Rawling T, et al., A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells. J Med Chem. 2017 Oct 26;60 (20) :8661-8666.