Antitumor agent-159
Product Specifications
Product Name Alternative
Pentacarboxybenzene
UNSPSC Description
Antitumor agent-159 (Compound 13b) targets the mitochondria and downregulates cardiolipin levels. Antitumor agent-159 inhibits the proliferation of cancer cell MDA-MB-231, arrests the cell cycle at sub-G1 phase, and induces apoptosis in MDA-MB-231. Antitumor agent-159 exhibits antitumor efficacy in MDA-MB-231 xenograft mouse models[1].
Target Antigen
Apoptosis; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-159.html
Smiles
ClC1=CC=C(C=C1C(F)(F)F)NC(NCCCCCCCCCCCCCCCC(O)=O)=O
Molecular Weight
493.00
References & Citations
[1]Rawling T, et al., A Novel Arylurea Fatty Acid That Targets the Mitochondrion and Depletes Cardiolipin To Promote Killing of Breast Cancer Cells. J Med Chem. 2017 Oct 26;60(20):8661-8666.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116447/Antitumor-agent-159-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116447/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Available Sizes
Curated Selection
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