GuaB-IN-1
GuaB-IN-1 (Compound 15) exhibits high potency against M.tb with a MIC value of 0.25 μM. GuaB-IN-1 has a favorable 28% hERG inhibition profile at 10 μM. GuaB-IN-1 is promising for research of tuberculosis[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Anti-infection; Vitamin D Related/Nuclear Receptor
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/guab-in-1.html
Smiles
C[C@H](C1=NN=CC(N2N=C(Cl)C=C2)=C1)OC(C=C3)=CC(N4CCOCC4=C5)=C3C5=O
Molecular Formula
C21H18ClN5O3
Molecular Weight
423.85
References & Citations
[1]Zhou Y, et al. Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis. Bioorg Med Chem Lett. 2024 Nov 12:130026.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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