Alternariol
Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II) . Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].
Product Specifications
CAS Number
[641-38-3]
UNSPSC
12352005
Hazard Statement
H300, H310, H330, H360
Target
Androgen Receptor; Apoptosis; Estrogen Receptor/ERR; Topoisomerase
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/alternariol.html
Purity
99.88
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=CC(O)=CC(O2)=C1C3=CC(O)=CC(O)=C3C2=O
Molecular Formula
C14H10O5
Molecular Weight
258.23
Precautions
H300, H310, H330, H360
References & Citations
Alternaria alternate
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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