(R, R) -CPI-1612
(R, R) -CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity[1].
Product Specifications
CAS Number
[2374972-35-5]
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-r-cpi-1612.html
Concentration
10mM
Purity
99.49
Solubility
DMSO : 130 mg/mL (ultrasonic)
Smiles
CN(N=C1)C=C1C(C=N2)=CC=C2NC([C@@H](C3=CC=CC=C3)NC[C@@H](C4=CC=C(C=C4)C#N)C)=O
Molecular Formula
C27H26N6O
Molecular Weight
450.53
References & Citations
[1]Jonathan E Wilson, et al. Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor. ACS Med Chem Lett. 2020 Apr 23;11 (6) :1324-1329.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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