1-Hydroxyrutecarpine

1-Hydroxyrutaecarpine (compound 1a) is a hydroxy-derivative of rutaecarpine. 1-Hydroxyrutaecarpine shows cytotoxicities with ED50s of 3.72, 7.44 µg/mL for P-388 and HT-29 cells, respectively. 1-Hydroxyrutaecarpine shows antiplatelet activity[1][2][3].

Product Specifications

CAS Number

[53600-24-1]

Product Name Alternative

1-Hydroxyrutaecarpine

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Drug Derivative

Type

Natural Products

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/1-hydroxyrutecarpine.html

Solubility

10 mM in DMSO

Smiles

O=C1N2C(C(NC3=C4C=CC=C3)=C4CC2)=NC5=C1C=CC=C5O

Molecular Formula

C18H13N3O2

Molecular Weight

303.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bruno Danieli; et al. 1-Hydroxyrutaecarpine from Euxylophora paraënsis. Phytochemistry, 1974 , 13 (8), 1603–1606.|[2]Chen JJ, et al. New indolopyridoquinazoline, benzo[c]phenanthridines and cytotoxic constituents from Zanthoxylum integrifoliolum. Planta Med. 2005 May;71 (5) :470-5.|[3]Sheen WS, et al. Indolopyridoquinazoline alkaloids with antiplatelet aggregation activity from Zanthoxylum integrifoliolum. Planta Med. 1996 Apr;62 (2) :175-6.