Stemregenin 1 (GMP)

Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001) . GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC50 of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the treatment of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases[1][2][3][4].

Product Specifications

CAS Number

[1227633-49-9]

Product Name Alternative

SR1 (GMP)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Aryl Hydrocarbon Receptor

Type

GMP Small Molecules

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/stemregenin-1-gmp.html

Purity

99.7

Solubility

10 mM in DMSO

Smiles

CC(C)N1C2=NC(C3=CSC4=C3C=CC=C4)=NC(NCCC5=CC=C(O)C=C5)=C2N=C1

Molecular Formula

C24H23N5OS

Molecular Weight

429.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Tao L, et al. StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells. J Stem Cells Regen Med. 2017 Dec 18;13 (2) :75-79.|[2]Jackson CS, et al. Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 2017 May;21:124-131.|[3]Zhou S, et al. StemRegenin 1 attenuates the RANKL-induced osteoclastogenesis via inhibiting AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. iScience. 2024 Apr 6;27 (5) :109682.|[4]Boitano AE, et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. Science. 2010 Sep 10;329 (5997) :1345-8.