Human Neuroserpin (Recombinant)

<strong>Human Neuroserpin (Recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2010272_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH: </strong>7.4_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> highly pure human neuroserpin expressed in HEK293 cells. Neuroserpin acts as a serine protease inhibitor mainly produced in the nervous system._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuNeuroserpin; Peptidase inhibitor 12; Serpin I1; SERPINI1_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Lee TW, Tsang VW, Loef EJ, Birch NP. Physiological and pathological functions_x000D_ of neuroserpin: Regulation of cellular responses through multiple mechanisms._x000D_ Semin Cell Dev Biol. 2017 Feb;62:152-159._x000D_ _x000D_ 2: Roussel BD, Lomas DA, Crowther DC. Progressive myoclonus epilepsy associated_x000D_ with neuroserpin inclusion bodies (neuroserpinosis). Epileptic Disord. 2016 Sep_x000D_ 1;18(S2):103-110._x000D_ _x000D_ 3: Loef EJ, Brooks AES, Lorenz N, Birch NP, Dunbar PR. Neuroserpin regulates_x000D_ human T cell-T cell interactions and proliferation through inhibition of tissue_x000D_ plasminogen activator. J Leukoc Biol. 2020 Jan;107(1):145-158._x000D_ _x000D_ 4: Adorjan I, Tyler T, Bhaduri A, Demharter S, Finszter CK, Bako M, Sebok OM,_x000D_ Nowakowski TJ, Khodosevich K, Møllgård K, Kriegstein AR, Shi L, Hoerder-_x000D_ Suabedissen A, Ansorge O, Molnár Z. Neuroserpin expression during human brain_x000D_ development and in adult brain revealed by immunohistochemistry and single cell_x000D_ RNA sequencing. J Anat. 2019 Sep;235(3):543-554._x000D_ _x000D_ 5: Reumann R, Vierk R, Zhou L, Gries F, Kraus V, Mienert J, Romswinkel E,_x000D_ Morellini F, Ferrer I, Nicolini C, Fahnestock M, Rune G, Glatzel M, Galliciotti_x000D_ G. The serine protease inhibitor neuroserpin is required for normal synaptic_x000D_ plasticity and regulates learning and social behavior. Learn Mem. 2017 Nov_x000D_ 15;24(12):650-659._x000D_ _x000D_ 6: Visentin C, Broggini L, Sala BM, Russo R, Barbiroli A, Santambrogio C, Nonnis_x000D_ S, Dubnovitsky A, Bolognesi M, Miranda E, Achour A, Ricagno S. Glycosylation_x000D_ Tunes Neuroserpin Physiological and Pathological Properties. Int J Mol Sci. 2020_x000D_ May 3;21(9):3235._x000D_ _x000D_ 7: Moriconi C, Ordoñez A, Lupo G, Gooptu B, Irving JA, Noto R, Martorana V,_x000D_ Manno M, Timpano V, Guadagno NA, Dalton L, Marciniak SJ, Lomas DA, Miranda E._x000D_ Interactions between N-linked glycosylation and polymerisation of neuroserpin_x000D_ within the endoplasmic reticulum. FEBS J. 2015 Dec;282(23):4565-79._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28255164/">8: Giampietro C, Lionetti MC, Costantini G, Mutti F, Zapperi S, La Porta CA._x000D_ Cholesterol impairment contributes to neuroserpin aggregation. Sci Rep. 2017 Mar_x000D_ 3;7:43669.</a>_x000D_ _x000D_ <strong>Products Related to Neuroserpin (Recombinant, Human)</strong><a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>