ATG7 Rabbit rabbit pAb

This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Product Specifications

Background

UniProt

O95352

Swiss Prot

O95352

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of ATG7

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF

Concentration

1 mg/ml

Dilution

IHC-p 1:50-300, WB 1:500-2000

Molecular Weight

78kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

78kD

Fragment

IgG

Subcellular Location

Cytoplasm . Preautophagosomal structure . Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. .

Other Product Names

Ubiquitin-like modifier-activating enzyme ATG7 (ATG12-activating enzyme E1 ATG7; Autophagy-related protein 7; APG7-like; hAGP7; Ubiquitin-activating enzyme E1-like protein)