A778317

A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid[1].

Product Specifications

CAS Number

[808756-64-1]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/a778317.html

Smiles

O=C(N[C@@H]1CCC2=C1C=CC(C(C)(C)C)=C2)NC3=CC=CC4=C3C=CN=C4

Molecular Formula

C23H25N3O

Molecular Weight

359.46

References & Citations

[1]Bianchi B R, et al. [3H] A-778317 [1- ((R) -5-tert-butyl-indan-1-yl) -3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 323 (1) : 285-293.