A778317
Product Specifications
UNSPSC Description
A778317 is a TRPV1 antagonists. A778317 can block changes in intracellular calcium levels mediated by TRPV1 receptors, with a pIC50 value of 8.31. A-778317 can also block the activation of natural rat TRPV1 receptors in dorsal root ganglion neurons by capsaicin and acid[1].
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/a778317.html
Smiles
O=C(N[C@@H]1CCC2=C1C=CC(C(C)(C)C)=C2)NC3=CC=CC4=C3C=CN=C4
Molecular Weight
359.46
References & Citations
[1]Bianchi B R, et al. [3H] A-778317 [1-((R)-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 323(1): 285-293.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121122/A778317-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121122/
Clinical Information
No Development Reported
CAS Number
808756-64-1
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