β-Thujaplicinol
β-Thujaplicinol (3-Hydroxy-5-isopropyltropolone) is an inhibitor of hepatitis B virus (HBV) ribonuclease H. β-Thujaplicinol inhibits RNAseHs of HBV genotypes D and H with IC50 values of 5.9 and 2.3 μM, respectively[1].
Product Specifications
CAS Number
[29346-20-1]
Product Name Alternative
3-Hydroxy-5-isopropyltropolone
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis; HBV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/β-thujaplicinol.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C1=CC(C(O)=C(C=C1)O)=O)C
Molecular Formula
C10H12O3
Molecular Weight
180.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Hu Y, et al. β-Thujaplicinol inhibits hepatitis B virus replication by blocking the viral ribonuclease H activity[J]. Antiviral research, 2013, 99 (3) : 221-229.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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