U-101958 (maleate)
Product Specifications
UNSPSC Description
U-101958 (PNU-101958) maleate is a highly selective ligand and antagonist for dopamine D4 receptor, with an IC50 of 2.7 nM. U-101958 maleate behaves as an agonist in HEK-293 cells expressing the human recombinant D4.4 receptor. U-101958 maleate is an antipsychotic[1][2].
Target Antigen
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/u-101958-maleate.html
Smiles
CC(C)OC1=CC=CN=C1N(C)C2CCN(CC2)CC3=CC=CC=C3.O=C(/C=C\C(O)=O)O
Molecular Weight
455.55
References & Citations
[1]Gazi L, et al. The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. Br J Pharmacol. 1998 Jul;124(5):889-96.|[2]De La Garza R 2nd, et al. [(3)H]PNU-101958, a D(4) dopamine receptor probe, accumulates in prefrontal cortex and hippocampus of non-human primate brain. Synapse. 2000 Sep 1;37(3):232-44.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123663/U-101958-maleate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123663/
Clinical Information
No Development Reported
CAS Number
224170-09-6
Curated Selection
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