(S) -VU0637120
(S) -VU0637120 is a Y4R antagonist that effectively reduces the binding response of its endogenous ligand, pancreatic polypeptide (PP), on Y4R, with an IC50 value of 2.7 μM. (S) -VU0637120 binds to the allosteric site of Y4R, which is located in the core region of the Y4R transmembrane structure, near the binding pocket of pancreatic polypeptide (PP), with a KB value of 300-400 nM. (S) -VU0637120 holds potential for research in the field of metabolic diseases[1].
Product Specifications
CAS Number
[1175940-86-9]
UNSPSC
12352005
Target
Neuropeptide Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s-vu0637120.html
Purity
99.5
Smiles
O=C([C@H]1N(CCCC1)S(C)(=O)=O)NC2=NC3=CC(OCCO4)=C4C=C3S2
Molecular Formula
C16H19N3O5S2
Molecular Weight
397.47
References & Citations
[1]Schüß C, et al. Highly Selective Y Receptor Antagonist Binds in an Allosteric Binding Pocket. J Med Chem. 2021 Mar 11;64 (5) :2801-2814.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NPY Y4 receptor
Available Sizes
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