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CK-2-68

CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC50 of 40 nM[1].

Product Specifications

CAS Number

1361004-87-6

Product Name Alternative

N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ck-2-68.html

Purity

98.91

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C(C)=C(NC2=C1C=CC(Cl)=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F

Molecular Formula

C24H17ClF3NO2

Molecular Weight

443.85

References & Citations

[1]Esser L, et al., Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bc1 complexes. J Biol Chem. 2023 Jul;299 (7) :104860.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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