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DHFR-IN-17

DHFR-IN-17 (compound j9) is an oral active SaDHFR inhibitor with the IC50 of 0.97 nM. DHFR-IN-17 shows antibacterial activity against S. aureus with the minimum inhibitory concentration of 0.031 μg/mL[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dhfr-in-17.html

Solubility

10 mM in DMSO

Smiles

CC(C1=C(C=C(C(OCC2CC2)=C1)I)OC3=CN=C(N=C3N)N)C

Molecular Formula

C17H21IN4O2

Molecular Weight

440.28

References & Citations

[1]Huang Z, et al. Design, Synthesis, and Biological Evaluation of 5- (5-Iodo-2-isopropyl-4-methoxyphenoxy) pyrimidine-2,4-diamine (AF-353) Derivatives as Novel DHFR Inhibitors against Staphylococcus aureus. J Med Chem. Published online March 11, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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