Clemastine-d5 (fumarate)
Clemastine-d5 (fumarate) is the deuterium labeled Clemastine fumarate. Clemastine fumarate (HS-592 fumarate) is a selective histamine H1 receptor antagonist with IC50 of 3 nM.
Product Specifications
Product Name Alternative
HS-592-d5 (fumarate) ; Meclastine-d5 (fumarate)
UNSPSC
12352005
Target
Autophagy; Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Neurological Disease; Endocrinology
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1[C@@H](CCO[C@](C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])(C3=CC=C(Cl)C=C3)C)CCC1.O=C(O)/C=C/C(O)=O
Molecular Formula
C25H25D5ClNO5
Molecular Weight
464.99
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42 (2) : p. 227-34.|[3]Schran, H.F., et al., The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations. J Clin Pharmacol, 1996. 36 (10) : p. 911-22.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
H1 Receptor
Available Sizes
Frequently Asked Questions
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