B7/CD28 interaction inhibitor 1
B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1].
Product Specifications
CAS Number
[635324-72-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CD28
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ctla-4-inhibitor-1.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=C(F)C=C2)NC3=C4C(N(C)N=C4)=NC(C5=CC=CC(C(F)(F)F)=C5)=C31
Molecular Formula
C21H13F4N5O
Molecular Weight
427.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11 (13) :2991-3013.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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