LMP744 (hydrochloride)

LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].

Product Specifications

CAS Number

[308246-57-3]

Product Name Alternative

MJ-III65 (hydrochloride) ; NSC706744 (hydrochloride)

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/LMP744_hydrochloride.html

Purity

99.08

Solubility

DMSO : 105 mg/mL (ultrasonic)

Smiles

OCCNCCCN1C2=C(C(C3=CC(OCO4)=C4C=C23)=O)C5=CC(OC)=C(OC)C=C5C1=O.Cl

Molecular Formula

C24H25ClN2O7

Molecular Weight

488.92

References & Citations

[1]Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67 (2) :523-30.|[2]Antony S, et al. Bisindenoisoquinoline bis-1,3-{ (5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline) -6-propylamino}propane bis (trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70 (3) :1109-20.