LMP744 (hydrochloride)
LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity[1].
Product Specifications
CAS Number
[308246-57-3]
Product Name Alternative
MJ-III65 (hydrochloride) ; NSC706744 (hydrochloride)
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LMP744_hydrochloride.html
Purity
99.08
Solubility
DMSO : 105 mg/mL (ultrasonic)
Smiles
OCCNCCCN1C2=C(C(C3=CC(OCO4)=C4C=C23)=O)C5=CC(OC)=C(OC)C=C5C1=O.Cl
Molecular Formula
C24H25ClN2O7
Molecular Weight
488.92
References & Citations
[1]Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67 (2) :523-30.|[2]Antony S, et al. Bisindenoisoquinoline bis-1,3-{ (5,6-dihydro-5,11-diketo-11H-indeno [1,2-c]isoquinoline) -6-propylamino}propane bis (trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity. Mol Pharmacol. 2006 Sep;70 (3) :1109-20.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Topo I
Available Sizes
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