Anabasine (hydrochloride)
Product Specifications
UNSPSC Description
Anabasine ((S)-Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM)[1][2].
Target Antigen
nAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/plus-anabasine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.C1([C@H]2NCCCC2)=CC=CN=C1
Molecular Weight
198.69
References & Citations
[1]Green BT, et, al. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol Teratol. May-Jun 2010; 32(3): 383-90.|[2]Palmer-Young EC, et, al. Context-dependent medicinal effects of anabasine and infection-dependent toxicity in bumble bees. PLoS One. 2017 Aug 23; 12(8): e0183729.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W014928/Anabasine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W014928/
Clinical Information
No Development Reported
CAS Number
53912-89-3
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