Anabasine (hydrochloride)

Anabasine ((S) -Anabasine) hydrochloride is an alkaloid that found as a minor component in tobacco (Nicotiana) . Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs) . Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM) [1][2].

Product Specifications

CAS Number

[53912-89-3]

Product Name Alternative

(S) -Anabasine (hydrochloride) ; (+) -Anabasine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H225-H301+H311+H331-H370

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/plus-anabasine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.C1([C@H]2NCCCC2)=CC=CN=C1

Molecular Formula

C10H15ClN2

Molecular Weight

198.69

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P370+P378-P405-P501

References & Citations

[1]Green BT, et, al. Actions of piperidine alkaloid teratogens at fetal nicotinic acetylcholine receptors. Neurotoxicol Teratol. May-Jun 2010; 32 (3) : 383-90.|[2]Palmer-Young EC, et, al. Context-dependent medicinal effects of anabasine and infection-dependent toxicity in bumble bees. PLoS One. 2017 Aug 23; 12 (8) : e0183729.