ISAM-140

ISAM-140 (22b) is a potent and highly selective A2B adenosine receptor antagonist with a Ki of 3.49 nM[1].

Product Specifications

CAS Number

[932191-62-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/isam-140.html

Purity

99.85

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)N=C2NC3=CC=CC=C3N2C1C4=CC=CO4)OC(C)C

Molecular Formula

C19H19N3O3

Molecular Weight

337.37

Precautions

H315, H319, H335

References & Citations

[1]El Maatougui A, et al. Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes. J Med Chem. 2016 Mar 10;59 (5) :1967-83.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Adenosine A2B receptor (A2BR)

Available Sizes

Curated Selection

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