IDX184
IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM) [1][2].
Product Specifications
CAS Number
1036915-08-8
UNSPSC
12352005
Target
HCV; HCV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/idx184.html
Purity
99.80
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C[C@]([C@](O[C@@H]1CO[P](NCC2=CC=CC=C2)(OCCSC(C(C)(C)CO)=O)=O)([H])N3C(NC(N)=NC4=O)=C4N=C3)([C@@H]1O)O
Molecular Formula
C25H35N6O9PS
Molecular Weight
626.62
References & Citations
[1]Xiao-Jian Zhou , et al. Safety and Pharmacokinetics of IDX184, a Liver-Targeted Nucleotide Polymerase Inhibitor of Hepatitis C Virus, in Healthy Subjects. Antimicrob Agents Chemother. 2011 Jan;55 (1) :76-81.|[2]IN VITRO ANTIVIRAL ACTIVITY AND PHARMACOLOGY OF IDX184, A NOVEL AND POTENT INHIBITOR OF HCV REPLICATION.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
AN301294L 100 µL
Recombinant Histone H3 (Tri Methyl Lys36) Monoclonal Antibody
Sign In for Pricing
View Details 
ARP55279_P050 100 µL
Dak antibody - N-terminal region (ARP55279_P050)
Sign In for Pricing
View Details orb3114169 100 µg
Carboxypeptidase E/CPE Rabbit Polyclonal Antibody (Fluoro550)
Sign In for Pricing
View Details 