LY2562175
LY2562175 is a potent and selective FXR agonist, with an EC50 of 193 nM[1].
Product Specifications
CAS Number
[1103500-20-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Autophagy; FXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/LY2562175.html
Purity
99.49
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(C)C2=C1C=CC(N3CCC(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)CC3)=C2)O
Molecular Formula
C28H27Cl2N3O4
Molecular Weight
540.44
Precautions
H302, H315, H319
References & Citations
[1]Genin MJ, et al. Discovery of 6- (4-{[5-Cyclopropyl-3- (2,6-dichlorophenyl) isoxazol-4-yl]methoxy}piperidin-1-yl) -1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia. J Med Chem. 2015 Dec 24;58 (24) :9768-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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