Compound 48/80
Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].
Product Specifications
CAS Number
94724-12-6
Product Name Alternative
Poly-p-methoxyphenethylmethylamine
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/compound-48-80.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CNCCC1=CC(CC2=CC(CCNC)=CC=C2OC)=C(OC)C(CC3=CC(CCNC)=CC=C3OC)=C1
Molecular Formula
C32H45N3O3
Molecular Weight
519.72
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
Int Immunopharmacol. 2025 May 19:159:114880.|J Invest Dermatol. 2025 Nov 4:S0022-202X (25) 03517-1.|SSRN. 2025 Nov 25.
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