Compound 48/80

Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].

Product Specifications

CAS Number

[94724-12-6]

Product Name Alternative

Poly-p-methoxyphenethylmethylamine

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/compound-48-80.html

Purity

99.98

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CNCCC1=CC(CC2=CC(CCNC)=CC=C2OC)=C(OC)C(CC3=CC(CCNC)=CC=C3OC)=C1

Molecular Formula

C32H45N3O3

Molecular Weight

519.72

References & Citations

[1]Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7 (12) :e52104. |[2]Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60 (1) :117-124. |[3]Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119 (1) :1-6.