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Cariprazine-d6

Cariprazine-d6 is a deuterium labeled Cariprazine. Cariprazine Cariprazine is an antipsychotic agent that exhibits high affinity for the D3 (Ki of 0.085 nM) and D2 (Ki of 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki of 2.6 nM) [1].

Product Specifications

CAS Number

1308278-67-2

Product Name Alternative

RGH-188-d6

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319

Target

5-HT Receptor; Dopamine Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

98.74

Solubility

DMSO : 2mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C([2H])([2H])[2H])C([2H])([2H])[2H]

Molecular Formula

C21H26D6Cl2N4O

Molecular Weight

433.45

Precautions

H302+H312+H332, H315, H319

References & Citations

[1] Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl) . 2011 Dec;218 (3) :579-8

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor; mLAG-3

Available Sizes

Frequently Asked Questions

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