Bisdemethoxycucurmin

Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases[1][2][3].

Product Specifications

CAS Number

[24939-16-0]

Product Name Alternative

Curcumin III; Didemethoxycurcumin

UNSPSC

12352005

Hazard Statement

H315, H319

Target

DNA/RNA Synthesis; Ferroptosis; P-glycoprotein

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bisdemethoxycucurmin.html

Purity

98.96

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C=C2

Molecular Formula

C19H16O4

Molecular Weight

308.33

Precautions

H315, H319

References & Citations

[1]Zhang P, et al. Cynarin alleviates intervertebral disc degeneration via protecting nucleus pulposus cells from ferroptosis. Biomed Pharmacother. 2023 Sep;165:115252.|[2]Nagabhushan, et al. Curcumin as an inhibitor of cancer. Journal of the American College of Nutrition 11.2. 1992. 192-198.|[3]Chearwae W, et al. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder. Biochem Pharmacol. 2004 Nov 15;68 (10) :2043-52.