1-Monomyristin

1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM) . 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans[1][2][3].

Product Specifications

CAS Number

[589-68-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Bacterial; Endogenous Metabolite; FAAH; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/1-monomyristin.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCC(OCC(O)CO)=O

Molecular Formula

C17H34O4

Molecular Weight

302.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Shimada H, et al. Biologically active acylglycerides from the berries of saw-palmetto (Serenoa repens) . J Nat Prod. 1997 Apr;60 (4) :417-8.|[2]Vandevoorde S, et al. Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase. Biochem Biophys Res Commun. 2005 Nov 11;337 (1) :104-9.|[3]Jumina, et al. Monomyristin and Monopalmitin Derivatives: Synthesis and Evaluation as Potential Antibacterial and Antifungal Agents. Molecules. 2018 Nov 29;23 (12) . pii: E3141