PT-ttpy
Pt-ttpy, a metallo-organic complex and potent G-quadruplex ligand, effectively triggers substantial telomere-related DNA damage in cancer cells by inhibiting telomerase and/or telomere functions, while also causing various chromatin abnormalities during mitosis, such as chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs) .
Product Specifications
CAS Number
[727721-37-1]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
DNA/RNA Synthesis; G-quadruplex; Mitosis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pt-ttpy.html
Purity
98.0
Solubility
DMSO : 0.2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[Cl-][Pt+2]12[N]3=C(C4=CC(C5=CC=C(C)C=C5)=CC(C6=[N]2C=CC=C6)=[N]41)C=CC=C3.[Cl-]
Molecular Formula
C22H17Cl2N3Pt
Molecular Weight
589.38
Precautions
H315, H319, H335
References & Citations
[1]P.P. Losada et al.Fresenius Journal of Analytical Chemistry1993
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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