CVN636
Product Specifications
UNSPSC Description
CVN636 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability[1].
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cvn636.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CS(=O)([C@H]1C2=CC=CC=C2OC[C@@H]1NC([C@H](C3=CC=C(C=C3)F)C)=O)=O
Molecular Weight
377.43
References & Citations
[1]Ayscough AP, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449.|[2]Dickson L, et, al. Discovery of CVN636: A Highly Potent, Selective, and CNS Penetrant mGluR7 Allosteric Agonist. ACS Med Chem Lett. 2023 Mar 2;14(4):442-449.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153615/CVN636-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153615/CVN636-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2226732-62-1
Available Sizes
Curated Selection
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