TG003

TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively[1].

Product Specifications

CAS Number

[719277-26-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TG003.html

Purity

99.57

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(/C=C1SC2=CC=C(C=C2N\1CC)OC)=O

Molecular Formula

C13H15NO2S

Molecular Weight

249.33

Precautions

H302, H315, H319

References & Citations

[1]Muraki M, et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004 Jun 4;279 (23) :24246-54.|[2]Marcel V, et al. Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response. Cell Death Differ. 2014 Sep;21 (9) :1377-87.|[3]Kurihara T, et al. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain. 2014 Mar 10;10:17.