SHP2-IN-13

SHP2-IN-13 is a highly selective and orally active SHP2 “tunnel site” allosteric inhibitor with an IC50 of 83.0 nM. SHP2-IN-13 has the potential for cancers bearing RTK oncogenic drivers and SHP2-related diseases research.

Product Specifications

CAS Number

[2951854-02-5]

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-13.html

Purity

99.41

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1(CCN(CC1)C2=NC=C(C(N)=N2)C(NC3=CN=CC=C3)=O)N

Molecular Formula

C16H21N7O

Molecular Weight

327.38

References & Citations

[1]Ruixiang Luo, et al. Discovery of a potent and selective allosteric inhibitor targeting the SHP2 tunnel site for RTK-driven cancer treatment. Eur J Med Chem. 2023 May 5;253:115305.