Tianeptine

Tianeptine is an atypical antidepressant. Tianeptine is a moderate-intensity agonist of the μ-opioid receptor (MOR), and to a lesser extent, is an agonist of the δ-opioid receptor (DOR) . Tianeptine is a glutamate modulator that can enhance AMPA receptor and antagonize NMDA receptor. tianeptine increases sensitivity of the α1 adrenergic receptor, which only manifests in chronic treatment. Tianeptine exerts neuroprotective effects under stress/inflammation-induced conditions, exhibiting anti-inflammatory and antioxidant properties. Tianeptine inhibits MMP-9 by suppressing the PI3K/Akt-mediated NF-κB pathway. Tianeptine can be used to alleviate symptoms of depression and anxiety, but does not cause sedative effects[1][2][3][4][5].

Product Specifications

CAS Number

[72797-41-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Akt; iGluR; MMP; NF-κB; Opioid Receptor; PI3K

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tianeptine.html

Purity

99.84

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C(CCCCCCNC(C1=CC=CC=C1N2C)C3=CC=C(C=C3S2(=O)=O)Cl)O

Molecular Formula

C21H25ClN2O4S

Molecular Weight

436.95

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Broqua P; Baudrie V; Chaouloff F Differential effects of the novel antidepressant tianeptine on L-5-hydroxytryptophan (5-HTP) -elicited corticosterone release and body weight loss. Eur Neuropsychopharmacol. 1992 Jun;2 (2) :115-20.|[2]Alamo C, et, al. Tianeptine, an atypical pharmacological approach to depression. Rev Psiquiatr Salud Ment. Jul-Sep 2019;12 (3) :170-186.|[3]Uzbay IT, et, al. Analgesic effect of tianeptine in mice. Life Sci. 1999;64 (15) :1313-9.|[4]Plaisant F, et, al. Neuroprotective properties of tianeptine: interactions with cytokines. Neuropharmacology. 2003 May;44 (6) :801-9.|[5]Jayasooriya RG, et al. Tianeptine sodium salt suppresses TNF-α-induced expression of matrix metalloproteinase-9 in human carcinoma cells via suppression of the PI3K/Akt-mediated NF-κB pathway. Environ Toxicol Pharmacol. 2014 Sep;38 (2) :502-9.