Oxyphenbutazone-d9

Oxyphenbutazone-d9 is the deuterium labeled Oxyphenbutazone (HY-B1355A) . Oxyphenbutazone is a phenylbutazone derivative, with anti-inflammatory effect. Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is the metabolite of Phenylbutazone (HY-B0230) . Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis[1][2][3].

Product Specifications

CAS Number

[1189693-23-9]

UNSPSC

12352005

Target

Bacterial; COX; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Immunology/Inflammation; Others

Field of Research

Cancer; Infection; Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C1N(C2=CC=C(C=C2)O)N(C3=CC=CC=C3)C(C1C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O

Molecular Formula

C19H11D9N2O3

Molecular Weight

333.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Saleem S, et al. Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway. Mol Cell Biochem. 2018 Jul;444 (1-2) :187-196.|[3]Gold B, et al. Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials. Proc Natl Acad Sci U S A. 2012 Oct 2;109 (40) :16004-11.