NTPO (trisodium)

NTPO trisodium is a DNA damage inducer, causing genomic DNA damage and fragmentation, activating ATR-mediated cell cycle checkpoints. The DNA damaging effects of NTPO trisodium are abrogated by base excision repair (BER) but not nucleotide excision repair (NER) [1].

Product Specifications

CAS Number

[7611-50-9]

Product Name Alternative

Nitrilotris (methylenephosphonic acid), trisodium salt

UNSPSC

12352200

Target

Others

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ntpo-trisodium.html

Solubility

10 mM in DMSO

Smiles

O=P(CN(CP(O)(O[Na])=O)CP(O)(O[Na])=O)(O[Na])O

Molecular Formula

C3H9NNa3O9P3

Molecular Weight

365.00

References & Citations

[1]Choi JY, et al. Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock. Oncotarget. 2016 May 31;7 (22) :32980-9.