NLRP3-IN-49
NLRP3-IN-49 (compound Z48) is a potent and specific NLRP3 inhibitor (IC50=0.26 μM in THP-1 cells, IC50=0.21 μM in mouse bone marrow macrophages) . NLRP3-IN-49 can directly bind to NLRP3 protein (Kd=1.05 μM), effectively preventing the assembly and activation of NLRP3 inflammasome, thereby exhibiting anti-inflammatory properties. NLRP3-IN-49 can be used in the study of inflammatory bowel disease[1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-49.html
Smiles
BrC1=CC=C(C=C1)/C=C(C(NCCC2=C(C=CC=C2)OC)=O)\CS(CCC#N)(=O)=O
Molecular Formula
C22H23BrN2O4S
Molecular Weight
491.40
References & Citations
[1]Zhang Z, et al. Design, Synthesis, and Bioevaluation of Novel NLRP3 Inhibitor with IBD Immunotherapy from the Virtual Screen[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TM33350L 100 Reactions
Saccharomyces cerevisiae TaqMan PCR Lyophilized Kits
Sign In for Pricing
View Details 
E-UNEL-H0036-02 15x 96 Tests
Uncoated Human D2D (D-Dimer) ELISA Kit
Sign In for Pricing
View Details 