Purified Anti-Human CD86 Antibody[IT2.2]

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.

LAB; ETC; FUN; CTLA-4 Counter-Receptor B; Early T-cell costimulatory molecule; CD28LG; B7-2; B7.2; B70; CD28LG2; LAB72; CD86; Activation B7-2 antigen; BU63; CTLA-4 Counter-Receptor B7.2; Early T-cell costimulatory molecule 1; ETC-1; FUN-1; T-lymphocyte activation antigen CD86; B7-2; Activation B7-2 antigen 3; B7 2; B72 antigen; B-lymphocyte activation antigen B7-2; B-lymphocyte activation antigen B7-2 2; CD28 antigen ligand 2; CD28 antigen ligand 2 2; Cd28l2; CD86 antigen; CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2 2; FUN 1; Ly58; Ly-58; MB7; MB7-2; Membrane glycoprotein; MGC34413; TS/A-2