(R) -Donepezil
(R) -Donepezil is a R-enantiomer of Donepezil. Donepezil is a specific and potent AChE inhibitor[1][2].
Product Specifications
CAS Number
142698-19-9
Product Name Alternative
(R) -E2020 (free base)
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/r-donepezil.html
Concentration
10mM
Purity
99.91
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1[C@H](CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4
Molecular Formula
C24H29NO3
Molecular Weight
379.49
Precautions
H315, H319, H320
References & Citations
[1]Lili W, et al. Steady-state plasma concentration of donepezil enantiomers and its stereoselective metabolism and transport in vitro. Chirality. 2013 Sep;25 (9) :498-505.|[2]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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