MET kinase-IN-4

MET kinase-IN-4 is an orally active Met kinase inhibitor. MET kinase-IN-4 has potent Met kinase inhibitory activity with an IC50 value of 1.9 nM. MET kinase-IN-4 can be used for the research of cancer[1].

Product Specifications

CAS Number

[888719-03-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

C-Met/HGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/met-kinase-in-4.html

Purity

99.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(NC=C5)=NC=C4)C(F)=C3

Molecular Formula

C25H16F2N4O3

Molecular Weight

458.42

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Kyoung Soon Kim, et al. Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities. J Med Chem. 2008 Sep 11;51 (17) :5330-41.