PIM447
PIM447 (LGH447) is a potent, orally available, and selective pan-PIM kinase inhibitor, with Ki values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis[1][2].
Product Specifications
CAS Number
1210608-43-7
Product Name Alternative
LGH447
UNSPSC
12352005
Hazard Statement
H301-H311-H331
Target
Apoptosis; Pim
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PIM447.html
Concentration
10mM
Purity
99.52
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(F)C(C2=C(F)C=CC=C2F)=N1)NC3=C([C@@H]4C[C@H](C)C[C@H](N)C4)C=CN=C3
Molecular Formula
C24H23F3N4O
Molecular Weight
440.46
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PIM1; PIM2; PIM3
Citation 01
Available Sizes
Frequently Asked Questions
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